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KMID : 0043319980210060782
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.782 ~ p.784
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Effect of Ginseng Total Saponin on Bovine Adrenal Tyrosine Hydroxylase
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Kim Hack-Seang
Zhang Yong-He
Fang Lian-Hua
Lee Myung-Koo
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Abstract
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Ginseng total saponin (GTS) can modulate dopaminergic activity at both presynaptic and postsynaptic dopamine receptors (Kim et al, 1998). The present study investigated t he effect of GTS on the bovine adrenal tyrosine hydroxylase (TH), which catalyze L/tyrosine to DOP. GTS inhibited the bovine adrenal TH by 42.4, 51.5 and 55.3% at concentrations of 40, 80 and 100/ml, respectively. The IC50 value of GTS was 77.5/ml. GTS exhibited noncompetitive inhibition with a substrate L-tyrosine. The Ki value was 155/ml.
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KEYWORD
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Ginseng total saponin, Bovine adrenal, Tyrosine hydroxylase, L-tyrosine, Non-competitive inhibition
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